Genetics, pedigrees, and the conditions they explain
Four articles: the six inheritance patterns, how a pedigree becomes a working algorithm, and two real conditions worked through in full.
The six inheritance patterns
Autosomes, gonosomes, genotype notation, and autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive, Y-linked, and mitochondrial inheritance, each with an example pedigree.
MethodologyFrom pedigree to algorithm
A pedigree is a graph. See how the rule for autosomal recessive inheritance becomes a precise, linear time algorithm, with pseudocode.
Condition deep diveDuchenne muscular dystrophy
X-linked recessive inheritance, how the loss of dystrophin tears muscle cell membranes, and why that one mechanism shortens life expectancy.
Condition deep diveCystic fibrosis
Autosomal recessive inheritance, how a broken chloride channel dehydrates mucus across the whole body, and how treatment has changed survival.
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